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32% Mortality Risk of Social Isolation

SOCIAL ISOLATION RISKS

Coalition for the Terminally Ill Disabled & Elderly

By Heather v. Wolf

The UK and several US States are planning an isolation event.

For over 20 years the scientific community has known that social Isolation carries a 32% mortality risk for human beings. [1,2,3,5,6]

What is the mortality rate of Covid in the absolute worst case scenario?

The WHO FDA and CDC have yet to produce a simple risk analysis nor a risk vs gain comparison on employing social isolation (lockdown) as a strategy to contain a coronavirus vs. other less economically and harmful to human health.

#socialisolation #covid_19 #kneejerkregulations

#32vs2  #IsolationRisks #CovidRiskanalysis #covidpreventionstrategies #CDC #FDA #USCongress

REFERENCES

1) True Cost of isolation

https://www.psychologytoday.com/us/blog/brainstorm/201812/new-look-links-between-isolation-and-mortality-risk

2.) Psychology today NIH study

https://pubmed.ncbi.nlm.nih.gov/25910392/

3.) Death rates

https://www.cdc.gov/nchs/fastats/deaths.htm

4.) World Health Organization

https://www.weforum.org/agenda/2020/04/we-could-be-vastly-overestimating-the-death-rate-for-covid-19-heres-why/

5.) Risk of Isolation

https://phys.org/news/2019-01-social-isolation-vary-rurality-demographics.html

6.) PNAS

https://www.pnas.org/content/110/15/5797

7.) ADA Law Addresses Social Isolation

https://www.disabled-world.com/disability/blogs/social-isolation.php

8.) How we measure impacts of Isolation

https://www.asaging.org/web-seminars/understanding-social-isolation-series-part-1-what-it-why-it-matters-and-how-its

9.) This NIH Study shows asymptomatic carriers are not contagious.

https://pubmed.ncbi.nlm.nih.gov/32513410/

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FDA RECALL NEEDED: Ibuprofen and all ACE2 Inhibiting Pain relievers during SARS-COV2 Epidemic

FOR IMMEDIATE RELEASE:

COALITION FOR THE TERMINALLY ILL DISABLED AND ELDERLY URGES HEALTH AUTHORITIES TO WARN THE PUBLIC ON THE RISKS OF ACE2 NSAIDS & STEROIDS DURING CORONAVIRUS OUTBREAK

PRESS CONTACT: 

Heather Wolf, TIDE Coalition

Tidecoalition@gmail.com

212-598-0335

March 26, 2020

Scientists around the world are currently studying the relationship between systemic anti-inflammatory medicines which produce ACE2 molecules and the progression and worsening of symptoms from Covid 19 into SARS and Acute respiratory failure in healthy individuals. [1,2,3,4]

Several peer-reviewed studies, lab experiments, comparative studies and post mortem exams show a strong correlation between the use of certain NSAIDS and other ACE2 modulating drugs or supplemental steroids with morbidity from SARS-COV2 in people without preexisting conditions. [1,2,3,5]

Scientists working with the virus and core biopsies of deceased individuals urged the World Health Organization(WHO) to issue a warning against ibuprofen(Advil) use during Covid outbreak. [1,2,3, 5]

Health authorities around the world are taking preemptive action to safeguard human life by urging their populations to stop taking over the counter Ibuprofen. [1,2,3,4,5,6]

CASE STUDIES

Reports began circulating in Europe and the United States of young people dying of Acute Respiratory Failure after Coronavirus infection. IBuprophen(Advil)- based over the counter cold medicine  was the common link. [5]

Studies reviewing post-mortem exams, puncture probes of liver, lung and GI tract and core tissue biopsies of lung, kidney and epithelial tissues of otherwise healthy deceased individuals showed evidence of ibuprofen or its analogues and metabolites in the lung Kidney and digestive tissues and a proliferation of ACE2 Enzymes. [1,2,3,4,5]

STUDIES 

Scientists working in labs with Covid-19 virus notified public health officials immediately for expert review of ACE2 Inhibitors role in worsening the impacts of the virus.

The chief pathway for the virus to enter, replicate and then kill the cells of the lung, liver, bile ducts and kidneys was ACE2 enzyme. 

Ibuprofen and other NSAIDS including Diclofenac were already under scrutiny due to their problematic cardiovascular profile of tripling stroke and heart attack risk in healthy people. 

A landmark 2017 European study discovered that Nsaids tripled risk of stroke, heart attack and sudden death in healthy people. This study resulted in the FDA publishing black box warnings on all NSAIDS based on that study.[6,8,9] 

A 2017 NIH study illustrates the adverse impacts of NSAIDS and Sars1. [6,7]

Researchers in a lab combined the Sars Cov2 virus with ibuprofen and discovered ibuprofen accelerates reproduction of the virus using the ACE2 pathway. 

Scientists found that Sars-COV2 binds to target cells via the angiotensin converting enzyme 2 (ACE 2) which are expressed by epithelial cells in the lungs, intestines, kidneys and blood vessels. These ACE2 enzymes act like food for the virus. [4,5,11]

This study explains the acceleration of tissue necrosis in otherwise healthy individuals due to the OTC drugs impact on ACE2 enzyme production. [1,4,5]

UNACCEPTABLE RISK 

ACE2 increasing NSAIDS increase viral destruction of lungs, intestines, kidneys and blood vessels. [1,7]

Public health officials are urged to place warnings on this drug class. 

WORKS CITED

1.) Sones M. Ibuprofen exacerbates coronavirus disease. Mar 03 2020. 

http://www.israelnationalnews.com/News/News.aspx/277457

2.) Mullin G. DRUG WARNING Stop taking ibuprofen to treat coronavirus, expert warns it ‘worsens infection’. The Sun. Mar 2020. 

https://www.thesun.co.uk/news/11193145/stop-taking-ibuprofen-coronavirus-worse/

3.) Science News. Steroids Should Be Avoided in Treatment of 2019-nCoV Coronavirus, Scientists Say. Feb 10. 2020. 

http://www.sci-news.com/medicine/steroids-treatment-2019-ncov-coronavirus-08107.html

4.) The Guardian. Can Ibuprofen make an infection worse? Mar 26 2020. 

https://www.theguardian.com/science/audio/2020/mar/26/covid-19-can-ibuprofen-make-an-infection-worse

5.) Kuba C. NIH. Journal of Nature. A Crucial Role of Angiotensin Converting Enzyme 2 (ACE2) in SARS Coronavirus-Induced Lung Injury. 2005. 

https://pubmed.ncbi.nlm.nih.gov/16007097/

6.) FDA. Drugs. com. Advil Black Box Warning Side Effects. 2017.

https://www.drugs.com/sfx/advil-side-effects.html

7.) Zhang et al. Intensive Care Medical Journal. Angiotensin-converting enzyme 2

(ACE2) as a SARS-CoV-2 receptor: molecular

mechanisms and potential therapeutic target.

https://link.springer.com/content/pdf/10.1007%2Fs00134-020-05985-9.pdf

8.) World Health Organization WHO. Mar 2020.

https://www.who.int/docs/default-source/coronaviruse/coping-with-stress.pdf?sfvrsn=9845bc3a_8

9.) Centers for Disease Control CDC. Coronavirus disease recommendations. Mar 2020.

https://www.cdc.gov/coronavirus/2019-ncov/if-you-are-sick/steps-when-sick.html

10.) National Institutes of Heath NIH. Center for research on Coronavirus 2019 (Sars Cov2) 

https://www.nih.gov/health-information/coronavirus

11.) Harvard Lancet. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? March 11, 2020

https://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(20)30116-8.pdf

KEY STUDIES

This NIH study shows the role of NSAIDS in Boosting Enzyme Activity In Sars cases. This was published in 2005. Coronavirus is known to the scientific community as Sars Cov 2, a more virulent form of the original Sars virus.